Associations of accumulated selected persistent organic pollutants in adipose tissue with insulin sensitivity and risk of incident type-2 diabetes

Continuous exposure to low doses of persistent organic pollutant (POPs), such as those occurring in the general population, might contribute burden type 2 diabetes mellitus (T2DM). However, evidences from longitudinal studies are scarce. We aimed explore associations accumulated POP with development T2DM by means 1) 16-year incidence disease, and 2) complementary cross-sectional analyses markers glucose homeostasis at recruitment. Organochlorine pesticide polychlorinated biphenyl (PCB) concentrations were analyzed adipose tissue samples incident cases retrieved clinical records. Homeostatic model assessment values insulin sensitivity/resistance ?-cell function recruitment calculated. Linear Cox-regression models performed. In individuals normal weight/overweight (n = 293), we observed positive dose–response relationships between studied POPs risk, particularly for hexachlorobenzene (HCB) [hazard ratio (HR): 3.96 4th quartile versus 1st (Q1); confidence interval (CI) 95%: 0.79, 19.71]. PCB-180 showed a but seemingly non-linear association risk [HR 3er (Q3) Q1: 6.48; CI 0.82, 51.29]. Unadjustment body mass index considerably increased magnitude associations. study 180), HCB inversely associated sensitivity positively resistance parameters. Our results suggest that higher specific may disrupt homeostasis, possibly contributing increase especially non-obese adults.